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Dec. 1, 2013
Sarkis RA, Thome-Souza S, Poh MZ, Llewellyn N, Klehm J, Madsen JR, Picard R, Pennell PB, Dworetzky BA, Loddenkemper T, Reinsberger C. Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy. Epilepsy Res. 2015 Sep;115:113-8. doi: 10.1016/j.eplepsyres.2015.06.005. Epub 2015 Jun 14. PMID: 26220387.
Following a generalized tonic clonic seizure (GTCS), some patients develop a period of post-ictal generalized electrical suppression (PGES) which may be associated with autonomic changes. Studies have proposed a correlation between the duration of PGES and the risk for sudden unexplained death in epilepsy (SUDEP). The degree of autonomic dysfunction during and after a seizure has also been linked to SUDEP. The effect of the patient’s age on the post-ictal autonomic response following a convulsion remains unclear and is the main focus of this study