Shuguang Zhang

Research Affiliate
Groups
Project Research

Receptor S-layer Electrical Nano Sensing Array (RESENSA)

A modular, membrane protein design based biomimetic sensing system named RESENSA (Receptor S-layer Electrical Nano Sens…
Project Research

Non-full-length G protein-coupled receptors: An unexpected discovery may lead to design new molecular devices

It was believed that functionalities of G protein-coupled receptors (GPCRs) require full-length sequences which are negated by residue dele…
Project Research

Designer molecular mops: Water-soluble cytokine receptors fused with Fc domain of IgG may be therapeutic for cytokine storms

In April 2019, Shuguang Zhang's lab started to use the QTY code to design a class of water-soluble cytokine receptors, including interferon…
Project Research

The QTY code: A simple tool for protein design

Structure and function studies of membrane proteins, particularly G protein-coupled receptors (GPCRs) and multipass transmembrane proteins,…
Project Research

Water-soluble transmembrane protein receptors with exchangeable and tunable ligand affinity

There are 20 chemokine receptors that bind their respective chemokines. It is not currently understood how these structurally similar recep…
Project Research

QTY CXCR4 becomes more hydrophilic and retains cell signaling activity

In collaboration with Prof. Horst Vogel and Dr. Horst Pick (EPFL, Lausanne, Switzerland).G protein-coupled receptors (GPCRs) are vital for …
Project Research

QTY code designs for water-soluble beta-barrel transmembrane proteins

In addition to a large number of membrane proteins that comprise most alpha-helix transmembrane segments, there are also many transmembrane…
Project Research

Membrane receptor-based high molecular density bioelectronic platform

In collaboration with Prof. Uwe Sleytr and Dr. Andreas Breitwieser (BOKU, Vienna, Austria).Bioelectronics is an emerging antidisciplinary f…