Climate change. Flawed algorithms. Deadly diseases. Tech monopolies. We are facing many existential challenges that need to be tackled head-on before it’s too late. Many of these problems are of our own making, consequences of our relentless push for progress. Fortunately, there are lots of people who are racing to save us from ourselves—progress we can definitely get behind. Whether it’s arming the immune system’s T-cells to precisely target tumors, developing eco-friendly alternatives to livestock-industry meat, or monitoring the internet’s hell sites to sniff out trouble, the 25 people and groups here offer real hope that we can fix the mistakes of the past and still have a chance for a future we can survive.