How can biological organisms be incorporated into product, fashion, and architectural design to enable the generation of multi-functional, responsive, and highly adaptable objects? This research pursues the intersection of synthetic biology, digital fabrication, and design. Our goal is to incorporate engineered biological organisms into inorganic and organic materials to vary material properties in space and time. We aim to use synthetic biology to engineer organisms with varied output functionalities and digital fabrication tools to pattern these organisms and induce their specific capabilities with spatiotemporal precision.